Last Author 2025
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
Peter C, Sathe A, Shashikumar N, ... Hohman TJ, Archer DB
JAMA Neurology
Neuroimaging & Computational Genetics
Derek B. Archer, PhD
Developing advanced neuroimaging and machine learning methods to identify brain signatures of neurodegeneration.
Assistant Professor of Neurology · Vanderbilt University Medical Center
2,060+
Citations
45+
Publications
4
Research Cohorts
h-25
H-Index
Research Focus
Areas of Investigation
🧠
Neuroimaging Biomarkers
MRI techniques and machine learning to identify brain signatures of neurodegeneration.
🧬
Computational Genetics
GWAS and polygenic risk scores linking genetic variation to brain structure.
🔬
White Matter Neurodegeneration
Diffusion MRI and tract-based analysis of white matter changes in aging and disease.
🤖
AI-Derived Brain Signatures
Deep learning for brain age prediction and biomarker discovery.
Selected Works
Featured Publications
1st Author 2024
Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease
Archer DB, Eissman JM, Mukherjee S, ... Dumitrescu L, Hohman TJ
Alzheimer's & Dementia
1st Author 2020
Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline
Archer DB, Moore EE, ... Jefferson AL, Hohman TJ
Neurobiology of Aging
1st Author 2019
Development and Validation of the Automated Imaging Differentiation in Parkinsonism (AID-P): A Multi-Site Machine Learning Study
Archer DB, Bricker JT, Chu WT, ... Vaillancourt DE
The Lancet Digital Health
Affiliations
Research Collaborations
VMAP
Vanderbilt Memory & Aging Project
Investigator
VADRC
Vanderbilt Alzheimer's Disease Research Center
Core Member
CNT
Center for Cognitive Neurology & Therapeutics
Faculty
VALIANT
Vanderbilt Lineages of Alzheimer's Neurodegeneration Trajectories
Investigator